Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders.

ABSTRACT: A key function of the perceptual system is to predict the (multi)sensory outcomes of actions and recalibrate these predictions in response to changing conditions. In schizophrenia spectrum disorders (SSD), impairments in this ability have been linked to difficulties in self-other distinction. This study investigated the neural correlates of the recalibration of action-outcome predictions to delays, the transfer of this process across sensory modalities, and whether participants with SSD exhibit alterations in the underlying neural processes. SSD participants and healthy controls (HC) underwent fMRI while exposed to delays between active or passive button presses and auditory outcomes. A delay detection task assessed recalibration effects on auditory perception (unimodal trials) and its tra

SUBMITTER: Schmitter CV 

PROVIDER: S-EPMC12858854 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature