Optimizing critical care pharmacotherapy: dynamic prospective evaluation of the medication regimen complexity-intensive care unit (MRC-ICU) score in critically ill patients.

ABSTRACT: Medication regimens in critically ill patients are generally complex, increasing the risk of drug-related problems (DRPs) and unfavorable outcomes. This study aimed to evaluate associations between medication complexity and clinical pharmacist (CP) interventions as well as clinical outcomes using the Medication Regimen Complexity-Intensive Care Unit (MRC-ICU) scoring tool. This prospective cohort study was conducted between June 2024 and April 2025 in a medical ICU of a tertiary university hospital. Throughout the study period, medication regimen complexity was assessed daily. CP interventions were systematically documented, and their potential impact was evaluated using the Clinical, Economic and Organizational (CLEO) tool. A total of 202 patients over 2,287 patient-days were evaluated, d

SUBMITTER: Balaban U 

PROVIDER: S-EPMC12858870 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature