ColoStem, a core oncofetal signature that identifies poor prognosis colorectal tumors.

ABSTRACT:

Background

We have previously shown that non-curative chemotherapy imposes fetal conversion and high metastatic capacity to cancer cells. Analysis of public colorectal cancer datasets confirms the existence of a oncofetal signature consisting of 28 upregulated and 8 downregulated genes that stratify patients with worse prognosis.

Methods

We have generated and analyzed a metacohort which integrates 1118 samples from six colorectal cancer public datasets and performed qPCR analysis of paraffin-embedded and plasma samples from our in-house cohort of colorectal cancer tumors.

Results

We uncovered a core oncofetal signature, which we have called ColoStem, composed of 5 genes upregulated and 3 genes downregulated that displays prognosis value in a multivariate analysis. We

SUBMITTER: Sole L 

PROVIDER: S-EPMC12858885 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature