Decoding gray matter, large-scale analysis of brain cell morphometry to inform microstructural modeling of diffusion MR signals.

ABSTRACT: Grey matter structure is central to neuroscience, as cellular morphology varies by type and is influenced by neurological conditions. Understanding these variations is essential for studying brain function and disease mechanisms. Diffusion-weighted MRI (dMRI) offers a non-invasive way to examine cellular microstructure, but its accuracy depends on identifying which morphological features influence its measurements. Despite increasing interest, no systematic study has defined the key neural cell features relevant to dMRI interpretation. Here, we analyzed over 11,800 three-dimensional cellular reconstructions across three species and nine cell types, establishing reference values for critical traits grouped into structural, shape, and topological categories. We also identified which of these

SUBMITTER: Aird-Rossiter C 

PROVIDER: S-EPMC12858938 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature