Polygenic risk for schizophrenia is associated with white matter microstructure, cognitive and mental health.

ABSTRACT: Schizophrenia is highly heritable, and polygenic risk score for schizophrenia (PRS_SCZ) has been associated with brain and behavior in healthy populations. However, the full associations of PRS_SCZ with brain white matter microstructure and cognitive and mental health outcomes, the potential effects of sex and areal deprivation on these associations, and the mediation of white matter microstructure for the associations between PRS_SCZ and behavioral outcomes remain largely unknown. In up to 300,000 participants from the UK Biobank, we investigated the associations of PRS_SCZ with eight white matter microstructure metrics of 48 tracts and 14 cognitive and mental health phenotypes, and we further tested the moderation of sex and index of multiple depri

SUBMITTER: Qian Q 

PROVIDER: S-EPMC12858994 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature