Distinct populations of lung capillary endothelial cells and their functional significance.

ABSTRACT: The role of the lung's microcirculation and capillary endothelial cells in normal physiology and the pathobiology of pulmonary diseases is obviously vital. The recent discovery of molecularly distinct aerocytes and general capillary (gCaps) endothelial cells by single-cell transcriptomics (scRNAseq) advanced the field in understanding microcirculatory milieu and cellular communications. However, increasing evidence from different groups indicated the possibility of a more heterogeneous nature of lung capillaries. Therefore, we investigated enriched lung endothelial cells by scRNAseq and identified five novel populations of gCaps with distinct molecular signatures and roles. Our analysis suggests that two major populations of gCaps that express Scn7a(Na⁺) and Clic4(Cl^-

SUBMITTER: James J 

PROVIDER: S-EPMC12859004 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature