Prognostic role of CDCA3 in lung adenocarcinoma with immune infiltration.

ABSTRACT: Lung cancer is a leading cause of cancer-related deaths, often resistant to conventional therapies like platinum-based chemotherapy. Identifying new biomarkers and therapeutic targets is essential for improving outcomes. In this study, we explored the role of CDCA3 in lung adenocarcinoma (LUAD) as a prognostic marker and its association with immune cell infiltration and immunotherapy. Using data from The Cancer Genome Atlas (TCGA), we evaluated CDCA3 expression and its prognostic significance through Kaplan-Meier survival analysis. Our results showed that CDCA3 was significantly upregulated in LUAD tumor tissues compared to normal tissues, with higher CDCA3 expression linked to poorer overall survival. Additionally, CDCA3 expression correlated with clinical features such as age, gender, ca

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12859040 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature