The Spanish Polygenic Score reference distribution: a resource for personalized medicine.

ABSTRACT: Here we present the Polygenic Score (PGS) distributions for 3124 common diseases and quantitative traits observed in the Spanish population. To achieve so, the genomes and exomes of 2190 unrelated individuals of Spanish ancestry were used. The analysis covered a wide range of diseases and traits, including both complex disorders, such as various types of cancer, and disorders associated with the digestive, cardiovascular, neuronal, and immune systems, as well as quantitative traits like hematological and anthropometric measurements. The resulting PGS distributions provide valuable insights into the genetic architecture of the Spanish population, offering a comprehensive framework for investigating disease susceptibility and potential risk factors in this specific population. The study has

SUBMITTER: Carmona R 

PROVIDER: S-EPMC12859145 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature