Emergence of Neisseria meningitidis ST-3587 harbouring bla _ROB-1 and exhibiting dual resistance to penicillin and ciprofloxacin, Spain, 2024.

ABSTRACT: BACKGROUNDDual penicillin- and ciprofloxacin-resistant Neisseria meningitidis causing invasive meningococcal disease (IMD) have recently emerged in association with sequence type (ST) 3587, harbouring ROB-1 β-lactamase (bla _ROB-1) and a mutated DNA gyrase (gyrA). These strains pose a threat to current antimicrobial treatment and prophylaxis.AIMWe aimed to characterise the first dual-resistant N. meningitidis ST-3587 isolates harbouring bla _ROB-1 and a mutated gyrA identified in Spain.METHODSThree N. meningitidis isolates encoding bla _ROB-1 were identified in 2024. They were characterised by whole genome sequencing to determine capsular genogroups, ST and genetic antimicrobial resistance markers. Dated

SUBMITTER: Roca-Grande J 

PROVIDER: S-EPMC12859395 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature