Computational modeling reveals cognitive processes in simple rodent depression tests.

ABSTRACT: Simple behavioral tests like the forced swim test (FST) and tail suspension test (TST) are widely used to assess depression-like behaviors in rodents, primarily measuring immobility time. However, this approach can oversimplify behavioral readouts and obscure cognitive processes driving behavior, leaving the relationship between increased immobility and cognitive biases unclear. Here, we developed the SwimStruggleTracker (SST) to extract fine-grained behavioral trajectories and integrate computational modeling to systematically analyze behavior. Our findings show that behavior in the FST and TST follows reinforcement learning principles involving learning, consequence perception, and decision-making. Notably, the cognitive processes underlying behavior differ between the two tests, challen

SUBMITTER: Li Z 

PROVIDER: S-EPMC12859488 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature