Synergistic roles of follicle-stimulating hormone and testosterone in Sertoli cell proliferation and testicular function in roosters.

ABSTRACT: Spermatogenesis relies on the intricate interactions between testicular somatic cells and germ cells. While follicle-stimulating hormone (FSH) and testosterone (T) are considered pivotal regulatory factors in this process, the mechanisms by which these hormones regulate the spermatogonial stem cell (SSC) microenvironment via Sertoli cells during testicular development in roosters remain unclear. Here, we examined how FSH and T regulate Sertoli-cell proliferation and the expression of glial cell-derived neurotrophic factor (GDNF) during rooster testicular development. We observed that at 4 weeks of age, the seminiferous tubules of roosters were fully developed, accompanied by the migration of spermatocytes into the lumen. At this stage, both serum and testicular levels of FSH and T were ele

SUBMITTER: Guo H 

PROVIDER: S-EPMC12859514 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature