Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study.

ABSTRACT:

Importance

Traumatic brain injury (TBI) has been associated with mortality and chronic conditions, including dementia. However, research is limited regarding the disease process by which TBI leads to long-term mortality.

Objective

To assess TBI incidence over decades and its association with long-term all-cause and dementia-related mortality among participants in the Framingham Heart Study (FHS), with the hypothesis that the association would be largely attributable to dementia-related mortality.

Design, setting, and participants

This cohort study used data from the original and offspring cohorts of the FHS, a multigenerational, community-based cohort study conducted from 1948 to 2022. Participants with TBI were matched 1:3 to unexposed participants based on birth yea

SUBMITTER: Burton R 

PROVIDER: S-EPMC12859724 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature