Baseline Nonperfusion and Deep Capillary Plexus Ischemia Predict Two-Year Retinal Nonperfusion Progression in Diabetic Retinopathy.

ABSTRACT:

Purpose

The purpose of this study was to determine which baseline factors, including ultra-widefield fluorescein angiography (UWF-FA) nonperfusion and macular optical coherence tomography angiography (OCTA) metrics, predict 2-year progression of retinal nonperfusion on UWF-FA in diabetic retinopathy (DR).

Methods

This prospective observational study included 73 patients (110 eyes) with diabetes across the spectrum of DR severity, followed for 2 years. Retinal nonperfusion was manually quantified as ischemic index, and progression was calculated as the 2-year minus baseline ischemic index for gradable retina. For receiver operating characteristic (ROC) analyses, progression was further defined as a binary event when the 2-year ischemic index increase exceeded two standard dev

SUBMITTER: Busza AM 

PROVIDER: S-EPMC12859726 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature