Circulating Tumor Cells in Uveal Melanoma: Multi-Marker Detection and Association With Disease State.

ABSTRACT:

Purpose

Uveal melanoma (UM) is primarily treated with eye-sparing radiotherapy, leaving limited tumor tissue for molecular analysis. Circulating tumor cells (CTCs) may offer a minimally invasive alternative for genomic tumor profiling. This pilot study evaluated the feasibility of a multi-marker CTC capture approach in UM patients at diagnosis, during fractionated stereotactic radiotherapy (fSRT), and at metastatic progression.

Methods

Patients with localized or metastatic UM were prospectively enrolled. Peripheral blood samples were collected at baseline, during fSRT, and on detection of metastases. CTCs were captured and enumerated using a multi-marker approach and fluorescence microscopy.

Results

A total of 76 patients were included: 68 with localized disease and e

SUBMITTER: de Bruyn DP 

PROVIDER: S-EPMC12859728 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature