Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo-Antigens.

ABSTRACT:

Problem

Maternal CD4 T cells are critical coordinators of maternal-fetal immune tolerance and immunity during pregnancy. Decidual regulatory T cells (T_REG) have been shown to provide essential immune suppressive functions to control allogeneic responses and inflammation. Activated CD4 memory T cells form the largest fraction of decidual T cells, yet their diversity, specificity, and functions remain largely undefined.

Method of study

Using high-dimensional flow cytometry (HDFC), computational and functional analysis to characterize decidual CD4 memory T-cell types and their functions.

Results

Two types of decidual CD4 T cells, the effector memory cells (T_EM), and CD69+ PD1+ resident memory cells (T_RM) with a strong capacity to respond

SUBMITTER: Koenig ZT 

PROVIDER: S-EPMC12859743 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature