Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis.

ABSTRACT: Liver fibrosis, caused by various chronic liver injuries, is one of the major causes of morbidity and mortality worldwide, but there is no efficient treatments in clinic until now. Cell-cell interactions in the injured liver microenvironment play critical roles in hepatic stellate cells (HSCs) activation and excessive extracellular matrix (ECM) deposition, but the exact mechanism involved and specific therapies remain elusive. Here, we report that an extracellular vesicles (EVs)-mediated profibrotic vicious circle might contribute to HSCs activation during the early stages of liver fibrosis development. In brief, increased EVs secretion was observed in patients with liver cirrhosis, mice with liver fibrosis, and injured hepatocytes, whereas pharmacological inhibition of EVs secretion parti

SUBMITTER: Sun J 

PROVIDER: S-EPMC12859877 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature