The association between serum antinuclear antibodies and premature ovarian insufficiency: a meta-analysis.

ABSTRACT:

Background

Autoimmune dysfunction is a recognized contributor to primary ovarian insufficiency (POI), and antinuclear antibodies (ANA) are widely used to assess autoimmune activity. Although many studies have examined the association between ANA and POI, their findings remain inconsistent. This meta-analysis aims to clarify the correlation between ANA positivity and POI and to evaluate the potential of ANA as a serological marker of autoimmune involvement in POI.

Methods

We systematically searched PubMed, EMBASE, Cochrane Library, CNKI, VIP, and WanFang Data for case-control studies published up to August 2024. Manual reference screening was also performed. Studies comparing antinuclear antibody (ANA) positivity between women with primary ovarian insufficiency (POI) and cont

SUBMITTER: Pi T 

PROVIDER: S-EPMC12859911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature