Toxoplasma gondii-induced ferroptosis contributes to acute lung injury in mice.

ABSTRACT:

Background

Toxoplasma gondii (T. gondii) is an important apicomplexan parasite that causes zoonotic toxoplasmosis in humans and animals. Acute T. gondii infection leads to systemic immunopathology that may manifest as lung injury or pulmonary embolism. Ferroptosis is an iron-dependent regulated cell death driven by lethal lipid hydroperoxide accumulation. Emerging evidence implicates ferroptosis in infection-related tissue damage; however, the role of ferroptosis in T. gondii-induced lung injury remains to be explored.

Methods

Mice were infected with T. gondii to establish a lung injury model. The body weight changes, survival rate, inflammatory cytokines, lung histopathology, and parasite burden were assessed. The key ferroptosis-related indicators involved in antioxidant,

SUBMITTER: Yuan X 

PROVIDER: S-EPMC12859960 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature