Exhaled breath volatile organic compounds (VOCs) detection methods: GC-MS versus eNose in COPD diagnosis-a systematic review and meta-analysis.

ABSTRACT:

Background

Volatile organic compounds (VOCs) derived from exhaled breath have been studied for their diagnostic potential in chronic obstructive pulmonary disease (COPD). However, the diagnostic efficacy of detection technologies of electronic nose (eNose) and gas chromatography-mass spectrometry (GC-MS) remains unclear. This study aims to systematically compare the diagnostic performance of these two methods in COPD diagnosis.

Methods

This review was conducted in accordance with PRISMA guidelines. Relevant studies were retrieved from databases including PubMed, EMBASE, Cochrane, SciFinder and Web of Science, with a cutoff date of April 30, 2025. Two researchers screened the literature, extracted data, and evaluated the quality of the studies using the QUADAS-2 tool. A bivar

SUBMITTER: Chai Y 

PROVIDER: S-EPMC12860002 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature