Elevated serum lipoprotein(a) as a prognostic marker for reduced survival in pancreatic cancer.

ABSTRACT:

Background

This study aimed to assess the prognostic significance of serum lipoprotein(a) [Lp(a)] levels regarding overall survival (OS) and progression-free survival (PFS) among patients diagnosed with pancreatic cancer (PC).

Methods

A retrospective cohort of 364 pathologically confirmed PC patients treated at the Affiliated Hospital of Qingdao University between January 2019 and December 2022 was analyzed. The optimal cutoff for Lp(a) was identified using X-tile software, allowing categorization into high and low Lp(a) groups. To minimize selection bias, propensity score matching (PSM) was utilized. Survival outcomes were compared using Kaplan-Meier curves and log-rank tests. Cox proportional hazards models were applied to identify independent prognostic variables affectin

SUBMITTER: Liu J 

PROVIDER: S-EPMC12860003 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature