Bioavailable testosterone reduces the risk of lung squamous cell carcinoma: a comprehensive data study.

ABSTRACT:

Background

The association between testosterone and lung cancer remains unclear. This study investigates the relationship between testosterone levels and lung cancer risk, focusing on bioavailable testosterone levels (BTLs), total testosterone levels (TTLs), and sex hormone-binding globulin (SHBG) in relation to lung cancer subtypes.

Methods

We utilized bidirectional and multivariable Mendelian randomization (MR) analyses based on genome-wide association studies (GWAS) to assess causal links. To validate the findings clinically, immunohistochemical (IHC) staining for androgen receptor (AR) expression and survival analyses were conducted on a cohort of 90 patients with lung squamous cell carcinoma (LUSC).

Results

MR analysis demonstrated that higher BTLs were significa

SUBMITTER: Luo J 

PROVIDER: S-EPMC12860008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature