Engineered neutrophil membrane nanosystem for targeted siRNA therapy in myocardial ischemia-reperfusion injury.

ABSTRACT: Despite the widespread use of emergency coronary reperfusion therapy, effectively managing reperfusion-induced myocardial injury remains a major clinical challenge. Neutrophil infiltration and the release of damage-associated molecular patterns (DAMPs), particularly the alarmin S100A8/A9, play pivotal roles in driving post-ischemic inflammation and exacerbating myocardial damage. To address this, we developed engineered neutrophil membrane-coated nanoparticles (ENM/RNA NPs) co-loaded with S100A9-targeting siRNA and G0-C14 to alleviate ischemia/reperfusion-induced cardiomyocyte injury. These biomimetic NPs leverage lymphocyte function-associated antigen-1 (LFA-1) overexpression on engineered neutrophil membranes to achieve inflammation-responsive myocardial targeting, thereby competitively

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12860009 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature