Aging-associated immune signature as a predictor of mortality in end-stage renal disease: results from the longitudinal iESRD study.

ABSTRACT:

Background

Accelerated immune aging has been implicated in patients with end-stage kidney disease, but a detailed examination of immune profiles correlated with long-term outcomes for these individuals has never been performed. Therefore, we conducted a prospective observational study ("Immunity in end-stage renal disease", iESRD) to investigate the effects of immune aging on mortality among these patients. An exploratory panel of immune cell subsets was analyzed by flow cytometry at baseline (neutrophils, CD3-negative lymphocytes, CD4 and CD8 T cell differentiation stages, and three subsets of monocytes). Immune cell distribution patterns were identified through data-driven principal component analysis (PCA).

Results

A total of 409 hemodialysis patients (mean age 61.7 years

SUBMITTER: Shu KH 

PROVIDER: S-EPMC12860072 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature