RNA modifications: roles in immune cell biology and tumor regulation.

ABSTRACT: In recent years, RNA modifications have been shown to play a key role in regulating immune cell functions, reshaping the tumor immune microenvironment (TIME), mediating immune escape, and influencing the efficacy of immunotherapy. These processes are central to the field of epitranscriptomics. Researchers have discovered various RNA modifications, such as N6-methyladenosine (m⁶A), 5-methylcytosine (m⁵C), N1-methyladenosine (m¹A), N7-methylguanosine (m⁷G), and N4-acetylcytosine (ac⁴C), that dynamically regulate the development, differentiation, activation, and functional state of immune cells through the " writers-readers-erasers " system-a set of enzymes that add, recognize, and remove these modifications-thus contributing to the formation and ev

SUBMITTER: Liu H 

PROVIDER: S-EPMC12860076 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature