Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.

ABSTRACT:

Background

Oxidative stress (OS) is a significant challenge in the in vitro embryo culture of patients of advanced age. The Erzhi Tiangui (EZTG) formula has been shown to alleviate OS-induced apoptosis in granulosa cells (GCs) of patients undergoing in vitro fertilization (IVF) cycles. This study aimed to investigate the protective effects and underlying mechanisms of the EZTG formula on OS and apoptosis in GCs of patients with advanced age.

Methods

A total of 240 patients aged 35 to 42 years were randomly assigned to either the experimental group (EZTG formula) or the control group (placebo). The experimental group received 3 g of EZTG formula three times daily, starting from the menstrual period preceding the IVF cycle for approximately 45 days, while the control group rec

SUBMITTER: Xiufang L 

PROVIDER: S-EPMC12860082 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature