Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C.

ABSTRACT:

Background

Cystatin C may better assess cardiovascular risk than serum creatinine for kidney function, but its accuracy may vary by sex. We evaluated sex differences in cardiac risk using estimated kidney function from either biomarker.

Methods

We included all adults from the UK Biobank without prior cardiac event who had kidney function and baseline data. We defined cardiac events and deaths using ICD-10 codes in hospital or death records. We fitted cause-specific Cox models to evaluate sex differences in cardiac outcomes using estimated glomerular filtration (mL/min/1.73m²) from serum creatinine (eGFRCr), cystatin C (eGFRCys) and both (eGFRCr-Cys).

Results

Among 394,920 adults (55% female), 19,689 (9%) females and 28,540 (16%) males had cardiac events. In

SUBMITTER: De La Mata NL 

PROVIDER: S-EPMC12860083 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature