Optimizing mandibular bone defect reconstruction using adipose-derived stem cells on 3-dimensionally printed polycaprolactone/xenograft scaffolds in canine model.

ABSTRACT:

Background

Mandibular bone defects present significant challenges in reconstructive surgery due to their complex structure, and the body's limited ability to heal these areas naturally. Tissue engineering provides a promising solution, combined with stem cell therapy to overcome these obstacles. This study investigated the effects of adipose-derived mesenchymal stem cells (ADSCs) cultured on novel three-dimensional (3D)-printed polycaprolactone/xenograft scaffolds on the reconstruction and regeneration of segmental mandibular bone defects in canine models.

Methods

3D-printed personalized PCL/xenograft scaffolds were designed and fabricated. After isolation and cultivation of canine ADSCs from their falciform tissues, they were seeded on 3D-printed scaffolds sterilized by gam

SUBMITTER: Mahdigholi N 

PROVIDER: S-EPMC12860160 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature