Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion.

ABSTRACT:

Background

Benign adrenal tumours, found in 1-7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical cortisol excess without manifestations of Cushing's syndrome (CS). MACS occurs in 20-50% of cases and is linked to increased cardiometabolic burden.

Methods

In a cross-sectional study, we analysed the 24-h urinary steroid metabolome of 1305 prospectively recruited patients (649 NFAT, 591 MACS, 65 adrenal CS) by tandem mass spectrometry. A sub-group (104 NFAT, 140 MACS, 47 adrenal CS) underwent untargeted serum metabolome analysis by mass spectrometry. Data were analysed using linear regression and supervised machine learning.

Findings

Alongside the expected increase in glucocorticoid excretion from NFAT over MAC

SUBMITTER: Prete A 

PROVIDER: S-EPMC12860258 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature