TRPM7 kinase regulates α-cell proliferation and glucagon production in mice.

ABSTRACT:

Objectives

Glucagon is essential for maintaining glucose homeostasis, yet the molecular mechanisms governing α-cell function remain incompletely understood. Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed ion channel with an intrinsic kinase domain, which regulates the mammalian target of rapamycin (mTOR) signaling in various cell types. Given the central role of mTOR in α-cell regulation, this study investigates how TRPM7 influences α-cell biology and examines whether its function is modulated through interaction with the mTOR signaling pathway.

Methods

Islets were isolated from wild-type (WT) mice and mice lacking TRPM7 kinase activity (Trpm7^R/R). Functional analyses included Bio-Plex assays, RNA sequencing, glucagon ELISA, qRT-PCR,

SUBMITTER: Boulassel S 

PROVIDER: S-EPMC12860271 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature