Photodynamic Therapy Plus Topical Corticosteroid for Erosive Oral Lichen Planus: A Randomized Clinical Trial.

ABSTRACT:

Introduction and aims

Erosive oral lichen planus (E-OLP) is a chronic inflammatory condition that poses a therapeutic challenge due to its recurrent nature and potential for malignant transformation. This study aims to evaluate the efficacy and safety of methylene blue-mediated photodynamic therapy (MB-PDT) combined with topical corticosteroid in treating E-OLP.

Methods

This single-centre, single-blinded, randomized, controlled trial was performed from March 2024 to August 2025. A total of 74 patients with E-OLP were randomly assigned to the MB-PDT group (n = 37) receiving MB-PDT plus 0.1% triamcinolone acetonide (TA) and the TA group (n = 37) treating with topical TA alone. The primary outcome was the clinical efficacy rate between the two groups.

Results

After 4 wee

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12860335 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature