A piperidinyl amide compound enhances Ca²⁺ signaling in cardiomyocytes by increasing activity of Ca²⁺ pump.

ABSTRACT: In adult cardiomyocytes, the type 2a sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA2a) plays a vital role in intracellular Ca²⁺ regulation. Reduced SERCA2a function has been associated with decreased myocardial contraction and cardiac output in several heart diseases. Consequently, increasing SERCA2a activity is a high-priority target for treating cardiac pathologies associated with abnormal Ca²⁺ homeostasis. In our previous SERCA ATPase-based screening study, we identified several small molecules as potential activators of SERCA2a function, including Compound 9, a piperidinyl amide. With porcine cardiac sarcoplasmic reticulum (SR) preparations, we confirmed activation of both SERCA2a ATPase and Ca²⁺-uptake activities. In the current study, we an

SUBMITTER: Bovo E 

PROVIDER: S-EPMC12860338 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature