Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease.

ABSTRACT:

Background and objective

The glymphatic system constitutes a brain-wide perivascular network responsible for brain metabolic waste removal, which may underlie pathogenesis in cerebral small vessel disease (CSVD). This study aimed to explore the associations of glymphatic function, assessed using multi-modal MRI indices, and both brain atrophy and cognitive impairment in CSVD.

Methods

The study included 160 participants comprising 120 patients with CSVD, including 52 without cognitive impairment (CSVD-NCI) and 68 with mild cognitive impairment (CSVD-MCI), alongside 40 healthy controls (HCs). All participants underwent neuropsychological and multi-modal neuroimaging assessments. Glymphatic function was assessed using four complementary MRI indices: choroid plexus (CP) volume,

SUBMITTER: Ai L 

PROVIDER: S-EPMC12860371 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature