Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots.

ABSTRACT: Pythiosis, caused by the oomycete Pythium insidiosum, is a worrying disease with its challenging treatment due to the phylogeny of the pathogen. Natural products are a promising alternative in the treatment of diseases. Cordia insignis (Boraginaceae) is a poorly studied species, but Cordia species exhibit broad bioactivity. This study investigated phytochemically the roots of the species and evaluated the anti-oomycete activity of the crude extract (CE) and fractions against P. insidiosum. Seven compounds were isolated and identified, including β-sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucopyranosyl, tridecanoic acid, scoparone, and gracicleistanthoside. The steroids, saponin and coumarin, were reported of leaves and branches of C. insignis; the fatty acid and glycosid

SUBMITTER: de Oliveira RC 

PROVIDER: S-EPMC12860512 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature