Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC-HRMS/MS, Molecular Docking, and ADMET Analysis.

ABSTRACT: Traditional medicinal plants are valuable sources of bioactive compounds used for therapeutic purposes. Haloxylon articulatum, a halophyte adapted to arid climate, has been consumed to treat several health issues. This study explores the phytochemical richness, the antioxidant, and the anticancer activities of a hydroalcoholic extract of H. articulatum through liquid chromatography-high-resolution mass spectrometry/mass spectrometry (LC-HRMS/MS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) analysis, cytotoxicity testing, and computational analysis. Alkaloids, flavonoids, and phenolic acids were among numerous bioactive chemicals found within the extracts. The DPPH assay revealed a notable antioxidant activity. Using the cytotoxicity test, the major phytochemicals, N-caffeoyltyramine and sinapoylt

SUBMITTER: Abidi J 

PROVIDER: S-EPMC12860547 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature