Discovery of Suomilide and Cyanopeptolin Analogues by ¹⁵N Stable Isotope Labeling and Genome Mining of Cyanobacteria.

ABSTRACT: Cyanobacteria have been a promising source for natural product drug discovery for decades using mainly activity-guided approaches. More recently, genome mining and bioinformatics-guided approaches have become increasingly utilized in bacterial drug discovery and have proven to be successful in revealing novel metabolites predicted by biosynthetic gene clusters. However, detection and identification of these predicted metabolites can be difficult. Connecting nitrogen-containing natural products with the corresponding gene clusters encoding them in cyanobacteria can be aided by cyanobacteria's ability to incorporate inorganic nitrogen into their secondary metabolites. Feeding cyanobacteria with ¹⁵N-labeled and ¹⁴N nitrate and comparing the resulting metabolic profiles v

SUBMITTER: Chauvin IM 

PROVIDER: S-EPMC12860550 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature