Immune-mediated inflammatory disease and coronary calcium: Elevated baseline risk and attenuated prognostic gradient.

ABSTRACT:

Background

Immune-mediated inflammatory diseases (IMID) are associated with accelerated atherosclerosis, yet it is unclear whether CT coronary artery calcium scoring (CTCS) captures this excess cardiovascular risk accurately. We hypothesized that in adults undergoing CTCS, IMID modifies the relationship between coronary artery calcium (CAC) score and incident major adverse cardiac events (MACE).

Methods

Among 43,420 individuals in the CLARIFY Registry (University Hospitals Cleveland, 2014-2020) who underwent no-cost CTCS scans, we identified 545 individuals with IMID. After propensity-score matching on age, sex, race, hypertension, diabetes, and smoking status with a 2:1 ratio, 1635 matched individuals were analyzed (545 with IMID and 1090 matched non-IMID controls). CAC was

SUBMITTER: Singh P 

PROVIDER: S-EPMC12860632 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature