Prognostic value of [¹⁸F]FET-PET in diffuse low-grade (grade 2) gliomas after the 2021 classification of CNS tumors.

ABSTRACT:

Purpose

Amino acid PET with [¹⁸F]-fluoroethylthyrosine ([¹⁸F]FET-PET) is frequently utilized in gliomas. Most studies on prognostication based on amino acid PET comprise mixed cohorts of brain tumors with low- and high-grade features. The objective of this study was to assess the potential prognostic value of [¹⁸F]FET-PET-based markers in the group of grade 2 adult-type diffuse gliomas, as defined by the WHO CNS 2021 classification.

Methods

Retrospectively, all therapy-naive patients having undergone [¹⁸F]FET-PET before maximal safe resection of grade II / 2 gliomas over a time of 2012-2022 were included. Diagnoses were updated according to the WHO CNS 2021 classification. [¹⁸F]FET-PET were quantitatively evaluated, incl

SUBMITTER: Muther M 

PROVIDER: S-EPMC12860753 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature