¹⁸F-NOTA-FAPI-04 PET/CT metabolic parameters combined with hematological biomarkers predict pathological complete response after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma.

ABSTRACT:

Objective

To investigate the predictive value of pretreatment ¹⁸F-NOTA-FAPI-04 PET/CT metabolic parameters combined with hematological biomarkers for pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC).

Methods

This retrospective study included 19 patients with locally advanced ESCC who underwent nCRT followed by surgery at Shandong Cancer Hospital from March 2022 to May 2023. Pretreatment clinical baseline data, ¹⁸F-NOTA-FAPI-04 PET/CT metabolic parameters, and hematological biomarkers were collected. Univariate and multivariate logistic regression analyses were used to select predictive parameters. A logistic regression model was constructed to pred

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12860807 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature