Volume histogram analysis of whole-lung CT: differentiating usual from nonspecific interstitial pneumonias and predicting prognosis.

ABSTRACT:

Purpose

Low agreements among experts for differentiating usual interstitial pneumonia (UIP) from nonspecific interstitial pneumonia (NSIP) motivate the use of automated imaging diagnosis. Volume histogram analysis (VHA) of the lung parenchyma using computer-aided diagnostic software is more straightforward to perform and interpret than radiomics. To assess whether a predictive model generated by VHA (VHA model), using voxel data of each lung lobe obtained via whole-lung CT, can differentiate radiological UIP from NSIP, and to explore the relationship between VHA model outcomes and patient prognosis.

Materials and methods

This study included 74 patients from one university hospital (cohort A: 47 patients with idiopathic pulmonary fibrosis [IPF]/UIP and 27 with idiopathic NSIP

SUBMITTER: Chikasue T 

PROVIDER: S-EPMC12860808 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature