[¹⁸F]FDG-PET reveals early postoperative cortical dysfunction after subthalamic nucleus deep brain stimulation in Parkinson's disease.

ABSTRACT:

Purpose

Motor improvement and neuropsychiatric symptoms may immediately follow implantation of subthalamic nucleus deep brain stimulation (STN-DBS) electrodes in Parkinson's disease (PD). We investigated the impact of electrode implantation prior to stimulation on transient dysfunction using cerebral [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET). Additionally, we sought to identify clinical and imaging variables associated with neuropsychiatric side effects (SE).

Methods

This retrospective analysis included thirteen patients with advanced PD, receiving [¹⁸F]FDG-PET scans preoperatively and within three weeks (median 6 days) after STN-DBS surgery. We analyzed changes of regional metabolism in a voxel-wise manner and with

SUBMITTER: Volz C 

PROVIDER: S-EPMC12860824 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature