DAPL1 is activated by Np63 and GRα and regulates lipid metabolism.

ABSTRACT: Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer occurrences and is divided into largely Adenocarcinoma (LUAD), Squamous cell carcinoma (LUSC), and Large cell carcinoma. In this study, using RNA-seq data between cancer tissues and adjacent normal tissues of 5 LUAD and 4 LUSC patients, we found that a Death associated protein like 1 (DAPL1) was highly expressed in squamous cell carcinoma but not in adenocarcinoma. Through the RNA-seq analysis, we found that lipid metabolic pathway genes Fdft1, Pcyt1a, and Sptlc1 correlate well with DAPL1 level changes in LUSC. We also found that Dapl1 was activated by Np63 and GRα monomer transcription factors. We generated a DAPL1 knockout mouse, which shows body weight and hair color changes, implying the role of DAPL1 in lipid

SUBMITTER: Bae HS 

PROVIDER: S-EPMC12860865 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature