Stereotactic radiosurgery in the management of cluster headache: evidence from a systematic review and meta-analysis.

ABSTRACT: Cluster headache (CH) is a highly disabling primary headache disorder, and a subset of patients remain refractory to medical or neuromodulatory therapies. Stereotactic radiosurgery (SRS) has been explored as a minimally invasive alternative, but reported outcomes are inconsistent. A systematic review and meta-analysis was performed following PRISMA guidelines. A comprehensive search of PubMed, Embase, Scopus, and Web of Science from inception to September 15, 2025, identified eligible studies. Treatment techniques varied across studies, including radiosurgical targeting of the gasserian ganglion or the trigeminal nerve at different locations, with or without concomitant targeting of the sphenopalatine ganglion (SPG). Across five studies involving 51 patients, SRS showed a notable early ben

SUBMITTER: Hajikarimloo B 

PROVIDER: S-EPMC12860871 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature