Evaluation of Magnetic Resonance Imaging-Derived Synthetic Computed Tomography in Prostate Cancer Carbon Ion Radiotherapy: Impact of Fixation Shell.

ABSTRACT:

Purpose

Magnetic resonance imaging (MRI) offers superior soft-tissue contrast for prostate delineation, and MR-only radiotherapy eliminates computed tomography (CT)-MRI registration errors. Although synthetic CT (sCT) has been validated for photon and proton therapy, its clinical feasibility in carbon ion radiotherapy (CIRT) remains unclear, particularly because dose accuracy in CIRT is highly sensitive to stopping-power ratio (SPR) errors. This study evaluated the dosimetric accuracy of MRI-derived sCT for prostate CIRT, including the effect of a thermoplastic fixation shell used clinically but not visualized on MRI.

Methods

Twenty patients with prostate cancer underwent same-day planning CT (pCT) and MRI. sCT images were generated using the MRCAT algorithm (Philips Healthc

SUBMITTER: Ishizawa M 

PROVIDER: S-EPMC12860915 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature