Chronic Kidney Disease as a Risk Factor for Age-Related Macular Degeneration: A Prospective Cohort and Mendelian Randomization Analyses.

ABSTRACT:

Purpose

To evaluate shared genetic influences and investigate the association of chronic kidney disease (CKD) with the risk for advanced age-related macular degeneration (AMD).

Design

Prospective cohort study and 2-sample Mendelian randomization (MR) analyses.

Participants

Data from 430 016 participants in the UK Biobank cohort and summary statistics from the largest publicly available genome-wide association studies on estimated glomerular filtration rate (eGFR) (n = 1 004 040) and advanced AMD (n = 33 976; 16 144 cases) were analyzed.

Methods

Cox regression models were used to assess the association between CKD and incident AMD, adjusting for demographic, lifestyle, and clinical covariates. For MR analyses, we used the random-effects inverse-variance weighted

SUBMITTER: Hsiao YJ 

PROVIDER: S-EPMC12860926 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature