Plasma Proteomic of Adolescent Idiopathic Scoliosis.

ABSTRACT: Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity encountered in adolescents. Here we portray the plasma proteomic landscape of 235 AIS samples. Enrichment analysis demonstrate that proteins with the increased level in AIS are significantly enriched in pathways including muscle weakness, disorder of hormone, whereas proteins showed decreased level in healthy controls are mainly involved in pathways related to immune response. The weighted gene correlation network analysis analysis indicates unbalanced lipid and glucose metabolism due to the insulin signaling activation could affect the AIS progression. Molecular subtyping classifies AIS patients into three subtypes that connected with significantly different Cobb angle (the standard radiographic measure of spinal cu

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12860931 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature