Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility.

ABSTRACT:

Background

Allostatic load (AL)-the cumulative biological cost of lifelong stress-can disrupt immune homeostasis via hypothalamic-pituitary-adrenal-axis dysregulation and persistent sympathetic activation. Immune-mediated inflammatory diseases (IMIDs) are organ-specific chronic inflammatory disorders imposing a major public-health burden, yet their causal link with AL remains unclear.

Methods

In this prospective study of 186 310 UK Biobank participants, Cox proportional-hazards models quantified dose-response associations between AL and the incidence of ten IMIDs plus all-cause mortality. Interaction models evaluated the modifying effects of physical activity, ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and other lifestyle variables, and assessed gene-environment interplay u

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12860939 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature