Hormone Replacement Therapy and Cardiovascular Outcomes by Race and Ethnicity: MESA (Multi-Ethnic Study of Atherosclerosis).

ABSTRACT:

Background

There is mixed data regarding hormone replacement therapy (HRT) and cardiovascular disease (CVD), particularly on how timing of HRT initiation close to menopause may affect outcomes, and there is little data among different race/ethnicity groups.

Objective

The purpose of this study was to how HRT use and cardiovascular outcomes differ by race/ethnicity.

Methods

The Multi-Ethnic Study of Atherosclerosis is a prospective epidemiologic study of participants without CVD at enrollment. Outcomes were (1) all-cause mortality and (2) major adverse cardiovascular events (MACEs). Cox models were developed, focusing on the timing of HRT initiation and differences by race/ethnicity (White, Black, Hispanic, and Chinese).

Results

There were 2,427 postmenopausal wo

SUBMITTER: Flynn S 

PROVIDER: S-EPMC12860954 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature