Toward Predictive Coarse-Grained Simulations of Biomolecular Condensates.

ABSTRACT: Phase separation is a fundamental process that enables cellular organization by forming biomolecular condensates. These assemblies regulate diverse functions by creating distinct environments, influencing reaction kinetics, and facilitating processes such as genome organization, signal transduction, and RNA metabolism. Recent studies highlight the complexity of condensate properties, shaped by intrinsic molecular features and external factors such as temperature and pH. Molecular simulations serve as an effective approach to establishing a comprehensive framework for analyzing these influences, offering high-resolution insights into condensate stability, dynamics, and material properties. This review evaluates recent advancements in biomolecular condensate simulations, with a particular fo

SUBMITTER: Liu S 

PROVIDER: S-EPMC12860963 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature