The role of metabolic syndrome in osteoarthritis development: Is obesity the key driver?

ABSTRACT:

Objective

Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA).

Methods

Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by the presence of at least three out of five components: elevated waist circumference (WC), elevated plasma triglycerides, reduced HDL-cholesterol, elevated blood pressure, and hyperglycaemia. Individuals were followed from baseline until incident OA diagnosis in any joint (outcome), death, relocation outside Region Skåne/Region Uppsala, or December 31, 2022. Associations between metabol

SUBMITTER: Andrea D 

PROVIDER: S-EPMC12861020 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature