Prognostic significance of subsequent decline in LVEF in heart failure with improved ejection fraction - A report from the CHART-2 study.

ABSTRACT:

Background

Some patients of heart failure with improved ejection fraction (HFimpEF) have subsequent decline in left ventricular ejection fraction (LVEF) after improvement, and their prognosis is uncertain.

Aims

We aimed to examine the clinical characteristics and long-term prognosis of this sub-population of HFimpEF.

Methods

We examined 399 consecutive patients with HF with reduced ejection fraction (HFrEF, LVEF ≤ 40 %) with LVEF data at both baseline and follow-up in the CHART-2 Study. We classified them as follows; persistent HFrEF group (LVEF ≤ 40 % at 1-year and 2-year follow-up, n = 238), temporary HFimpEF group (≥10 % increase from baseline with LVEF > 40 % at 1-year follow-up but LVEF ≤ 40 % at 2-year follow-up, n = 22), and persistent HFimpEF group (≥10 % incr

SUBMITTER: Takigahira T 

PROVIDER: S-EPMC12861058 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature